Geisler, Matt , Schuette, Scott .
Bioinformatic applications in the research of the model moss Physcomitrella patens: using predicted protein-protein interaction to construct interacting and regulatory network.
Background: A plant interactome is a map of all physical interactions between all proteins, and is an essential part of systems biology. Predicted interactomes are the fore-runner to experimentally determined interaction maps and the only type of interactomic data that will likely be available for bryophytes in the foreseeable future. Plant interactomes and network visualization software are currently available but not sufficiently user friendly for non-bioinformatics specialists to take full advantage of these tools. Our workshop will provide instruction and demonstrations for participants to utilize the predicted interactomes generated for Arabidopsis (Geisler-Lee et al., 2007) and a pre-publication release of the Physcomitrella patens predicted interactome. Participants are encouraged to bring lists of their genes of interest to the workshop (use the old or new moss accession numbers) and can walk away with a map of all predicted interactions for their proteins. A moss predicted interactome allows significant progress in the identification and annotation of unknown genes, interacting partner genes, and the filling in of pathways in plant regulation, signaling and metabolism. While these predictions provide insight for only the portions of the genome which show evolutionary conservation with plants, fungi and animal model systems, they are not restricted to well characterized genes, and include many completely unknown yet conserved proteins.
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1 - Southern Illinois University Carbondale, Plant Biology, 1125 Lincoln Ave., LSII, Rm403, Carbondale, Illinois, 62901, USA
2 - Southern Illinois University, Department of Plant Biology, 1125 Lincoln Drive, Carbondale, Illinois, 62901-6509, USA
Presentation Type: Activities:Workshops
Location: 550B/Convention Center
Date: Sunday, August 1st, 2010
Time: 2:00 PM